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Tracking activity at near cellular resolution could reveal how different regions of the brain interact WASHINGTON – Researchers have developed a head-mounted miniature microscope that can be used to image activity from the entire outer part of the brain, or cortex, in freely behaving mice. When combined with implantable see-through skulls, the new microscope can capture the brain activity of mice for more than 300 days. Mice are often used to study the brain because they have many of the same brain structures and connectivity as humans. The new microscope, known as the mini-mScope, offers a...

Mini-Microscope Allows Brain Imaging of Freely Moving Mice in Real Time Source: Kateryna KDN/Science Photo Library/Getty Images April 7, 2021 Share Although brain imaging is performed on head-fixed mice, recording neural activity in freely behaving mice has remained a challenge. To address this, researchers report the development of a unique head-mounted mini-microscope device that allows them to image complex brain functions of freely moving mice in real time over a period of more than 300 days. The device, known as the mini-MScope, offers an important new tool for studying how neural activi...

New mini-microscope enables imaging of complex brain functions in freely moving mice Researchers from the University of Minnesota Twin Cities College of Science and Engineering and Medical School have developed a unique head-mounted mini-microscope device that allows them to image complex brain functions of freely moving mice in real time over a period of more than 300 days. The device, known as the mini-MScope, offers an important new tool for studying how neural activity from multiple regions of the outer part of the brain, called the cortex, contribute to behavior, cognition, and perceptio...

Loading video... VIDEO: Researchers at the University of Minnesota College of Science and Engineering used a unique mini-microscope device to image complex brain activity of mice that show multiple areas of the brain... view more  Credit: Rynes and Surinach, et al., Kodandaramaiah Lab, University of Minnesota Researchers from the University of Minnesota Twin Cities College of Science and Engineering and Medical School have developed a unique head-mounted mini-microscope device that allows them to image complex brain functions of freely moving mice in real time over a period of more tha...