Metformin for Diabetes in Pregnancy: Maybe Not, Trial Says
New trial complicates findings of previous studies
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New trial complicates findings of previous studies
The faster formulation led to fewer hypoglycemia events versus conventional insulin aspart
RELATED: Randomized Controlled Trial Suggests Metformin Offers Benefits During Pregnancy Researchers randomly assigned 502 pregnant women with type 2 diabetes who were using insulin to add metformin (1,000 milligrams twice daily) or a placebo to their treatment regimen. As women neared the end of pregnancy, at 34 weeks’ gestation, the participants on metformin had lower average fasting blood sugar levels than their counterparts who didn’t take metformin (41.0 versus 43.2 millimoles per mol) and used less insulin (1.1 units versus 1.5 units per kilogram [kg] per day). With metformin, wome...