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Researchers probe deeper into the neuronal mechanisms underlying olfactory dysfunction in Alzheimer's

Researchers probe deeper into the neuronal mechanisms underlying olfactory dysfunction in Alzheimer’s
Loss of smell or olfactory dysfunction is an early indication of the neurodegenerative Alzheimer s disease (AD) and appears in approximately 90% of all patients. While loss of smell is a major symptom, patients with AD are only unable to recognize specific odors and do not completely lose their sense of smell; this suggests a possible region-specific involvement of the olfactive center in the brain.
Amyloid β (Aβ), a toxic protein that accumulates in the brain is a known contributing factor in AD pathogenesis and is also present in the olfactory system that controls the sense of smell. However, the pathology and mechanisms of AD-specific olfactory dysfunction involving olfactory sensory neurons (OSNs) remain unclear. ....

Emily Henderson , Alzheimer Research , Professor Cheil Moon , Alzheimer 39s Disease , Mouse Model , எமிலி ஹென்டர்சன் , முதுமறதி ஆராய்ச்சி , சுட்டி மாதிரி ,

Full characterization of mammalian-produced SARS-CoV-2 receptor binding domains

A research paper recently uploaded to the preprint server bioRxiv by Dominguez-Vega et al. (23rd Feb, 2021) describes an in-depth structural analysis of the RBD of the spike protein expressed in mammalian Chinese hamster ovary (CHO) cells and human embryonic kidney (HEK293) cells, providing a new understanding of protein structure and function. ....

Michael Greenwood , Image Credit , Sars Cov 2 , Angiotensin Converting Enzyme 2 , Cho Cells , Corona Virus , Coronavirus Disease Covid 19 , Mass Spectrometry , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , மைக்கேல் கிரீன்வுட் , படம் கடன் , சோ செல்கள் , கொரோனா வைரஸ் , நிறை ஸ்பெக்ட்ரோமெட்ரி , சர்வதேச பரவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,

Anti-phospholipid antibodies in severely ill patients not distinctive to COVID-19, says study

A new study by researchers at the University of Toronto and the University of Calgary in Canada indicates that the presence of these antibodies correlates with more severe COVID-19 symptoms and signs. ....

Liji Thomas , Andrii Vodolazhskyi Shutterstock , University Of Toronto , University Of Calgary , Andrii Vodolazhskyi , Coronavirus Disease Covid 19 , Sars Cov 2 , Corona Virus , பல்கலைக்கழகம் ஆஃப் டொராண்டோ , பல்கலைக்கழகம் ஆஃப் கல்கரி , கொரோனா வைரஸ் ,

New biomarker could help identify people at risk of Alzheimer's disease

Early diagnosis of Alzheimer's disease has been shown to reduce cost and improve patient outcomes, but current diagnostic approaches can be invasive and costly. ....

Ronald Cowan , Todd Monroe , Ray Romano , Emily Henderson , College Of Graduate Health Sciences , Ohio State University , Nursing Science Program , University Of Tennessee Health Science Center , Alzheimer Association , Nursing Science Phd Program , Tennessee Health Science Center , Graduate Health , Associate Professor Todd Monroe , Alzheimer 39s Disease , Primary Care , ரொனால்ட் கோவன் , டாட் மன்ரோ , ராய் ரோமானோ , எமிலி ஹென்டர்சன் , கல்லூரி ஆஃப் பட்டதாரி ஆரோக்கியம் அறிவியல் , ஓஹியோ நிலை பல்கலைக்கழகம் , நர்சிங் அறிவியல் ப்ரோக்ர்யாம் , பல்கலைக்கழகம் ஆஃப் டென்னசி ஆரோக்கியம் அறிவியல் மையம் , முதுமறதி சங்கம் , நர்சிங் அறிவியல் ஃப்ட் ப்ரோக்ர்யாம் , டென்னசி ஆரோக்கியம் அறிவியல் மையம் ,

Inovio Pharma, Qiagen To Develop Next Gen Sequencing Companion Diagnostic For VGX-3100

Inovio Pharma, Qiagen To Develop Next Gen Sequencing Companion Diagnostic For VGX-3100
VENLO (dpa-AFX) - Inovio Pharmaceuticals Inc. (INO) and Qiagen N.V. (QGEN) announced Wednesday their collaboration to develop next generation sequencing or NGS companion diagnostic for Inovio s VGX-3100 for advanced cervical dysplasia.
The companies are extending their partnership for the development of liquid biopsy-based companion diagnostic products based on NGS technology to complement INOVIO s therapies.
The initial project in this expanded collaboration focuses on the co-development of a diagnostic test that identifies women who are most likely to benefit from clinical use of VGX-3100, INOVIO s immunotherapy to treat advanced cervical dysplasia associated with the human papillomavirus or HPV. ....

Inovio Pharmaceuticals Inc , Illumina Nextseq ,