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European universities and research institutes say rule changes by the US’s main health research funder will force them to hire staff to deal with vast amounts of new paperwork, potentially delaying projects and weakening transatlantic collaboration.
Constant exposure of cells to stressing agents, such as pathogens, may disturb an organism's normal functioning. To fight stress, cells have developed several coping mechanisms, including the inflammatory response.
In a new paper published in Science, EMBL Grenoble researchers provide essential insights on the molecular activation of the MAP kinase p38α, the final switch triggering the inflammatory response. Inflammation is a cellular coping mechanism when confronted with stress, such as an infection. However, too much inflammation can damage the functioning of cells and organs. This is the case with cytokine storms, inflammatory cascades that can lead to severe disease and death, recently highlighted during the COVID-19 pandemic. These results open up new directions to develop drugs to prevent cytokine...
The Diamond Light Source synchrotron in Oxford is to receive more than half a billion pounds to upgrade and expand its scientific capabilities.
A ground-breaking science facility which kickstarted the UK’s Covid-19 drug development and has advanced treatments for HIV and cancer has been granted a £500 million upgrade fund.