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DNA replication and repair is a constant process with implications for health challenges like cancer, infertility and more. Michael Trakselis, professor of biochemistry and director of graduate affairs in Baylor Chemistry and Biochemistry, is a leading researcher into this process.
Researchers reviewed the existing knowledge on the mechanisms through which DNA tumor viruses evade the antiviral immunity mediated through mis-incorporated uracil (U).
Faithful DNA replication is essential for all life. A multi-protein complex called the replisome contains all the enzymatic activities required to facilitate DNA replication, including unwinding parental DNA and synthesizing two identical daughter molecules. Faithful DNA replication can be challenged by both intrinsic and extrinsic factors, which can result in roadblocks to replication, causing incomplete replication, genomic instability, and an increased mutational load. This increased mutational load can ultimately lead to a number of diseases, a notable example being cancer. A key example o...
Nobody wants to be average. But for a long time, scientists have found it convenient to think of bacterial cells as just that: "average."
Observing the processes of life that occur in all cellular organisms at the level of single molecules has allowed a deeper understanding of the dynamic processes taking place in complex biological systems. There has been a strong growth in the application of molecular biophysics to visualize in real time the behaviour of single molecules within a reaction, transforming our perception of the molecular processes that occur within a cell. A multitude of proteins participates across the genome to support the processes of replication, transcription, translation, repair and recombination. The contin...