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Study reveals how cells build 'mini-muscles' underneath their nucleus

Study reveals how cells build mini-muscles underneath their nucleus
Research groups at the University of Helsinki uncovered how motor protein myosin, which is responsible for contraction of skeletal muscles, functions also in non-muscle cells to build contractile structures at the inner face of the cell membrane.
This is the first time when such mini-muscles , also known as stress fibers, have been seen to emerge spontaneously through myosin-driven reorganization of the pre-existing actin filament network in cells. Defects in the assembly of these mini-muscles in cells lead to multiple disorders in humans, and in the most severe cases to cancer progression. ....

Eteläuomen Läi , Jaakko Lehtimaki , Pekka Lappalainen , Emily Henderson , Hilife Institute Of Biotechnology , University Of Helsinki , Academy Professor Pekka Lappalainen , Docent Sari Tojkander , Veterinary Medicine , Cell Membrane , Super Resolution Microscopy , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் ஹெல்சின்கி , கால்நடை மருந்து , செல் சவ்வு , மன அழுத்தம் , அருமை தீர்மானம் நுண்ணோக்கி ,

A mechanism by which cells build 'mini-muscles' underneath their nucleus identified

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IMAGE: On the left: Super-resolution microscopy image of a migrating human osteosarcoma cell. Magenta marks focal adhesions, and green non-muscle myosin II (NMII). F-actin bundles are shown in grey. On the.
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Credit: Jaakko Lehtomäki
Research groups at the University of Helsinki uncovered how motor protein myosin, which is responsible for contraction of skeletal muscles, functions also in non-muscle cells to build contractile structures at the inner face of the cell membrane. This is the first time when such mini-muscles , also known as stress fibers, have been seen to emerge spontaneously through myosin-driven reorganization of the pre-existing actin filament network in cells. Defects in the assembly of these mini-muscles in cells lead to multiple disorders in humans, and in the most severe cases to cancer progression. ....

Eteläuomen Läi , Jaakko Lehtimaki , University Of Helsinki , Academy Professor Pekka Lappalainen , Docent Sari Tojkander , Veterinary Medicine , Cell Biology , Medicine Health , பல்கலைக்கழகம் ஆஃப் ஹெல்சின்கி , கால்நடை மருந்து , செல் உயிரியல் , மருந்து ஆரோக்கியம் ,