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How CRISPR-Based Gene Engineering Is Helping To Accelerate Alzheimer's Disease Research


Researchers from the National Institutes of Health (NIH) recently outlined plans in
Neuron of a project that aims to accelerate research on Alzheimer’s disease and related dementias (ADRD). The ambitious project – the Induced Pluripotent Stem Cell Neurodegenerative Disease Initiative (iNDI) – will model more than 100 mutations associated with ADRD in isogenic induced pluripotent stem cell (iPSC) lines.
To learn about some of the main challenges associated with generating a large library of edited iPSCs and the role that Synthego, a genome engineering company, is playing in the iNDI project, we spoke to Synthego’s CSO, Dr Robert Dean.
Anna MacDonald (AM): Why is reliance on a “one gene at a time” approach to Alzheimer’s disease research and therapeutic discovery insufficient? ....

United States , National Institutes Of Health , Pluripotent Stem Cell Neurodegenerative Disease Initiative , National Institutes , Eclipse Platform , ஒன்றுபட்டது மாநிலங்களில் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , தேசிய நிறுவனங்கள் , கிரகணம் நடைமேடை ,