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Adjuvant Abemaciclib Plus Endocrine Therapy Sustains iDFS, DRFS Benefit in HR+, HER2– Early Breast Cancer

Adjuvant treatment with the combination of abemaciclib and endocrine therapy (ET) maintained a benefit in invasive disease-free survival and distant relapse–free survival compared with ET alone in patients with hormone receptor-positive, HER2-negative, node-positive, high-risk early breast cancer. ....

Eli Lilly , David Hyman , Kaplan Meier , P Ann Onc , Nadia Harbeck , Breast Center , Department Of Gynecology , Cancer Center Munich , Ludwig Maximilians University Hospital , Comprehensive Cancer Center Munich , Lancet Oncology , Monarche Trial , Hr Positive Breast Cancer , Hormone Receptor Positive Breast Cancer , Esmo Congress ,

Adagrasib Added to Pembrolizumab Safely, Effectively Treats Advanced NSCLC in Phase 2 KRYSTAL-7 Trial

The phase 2 KRYSTAL-7 trial evaluated adagrasib plus pembrolizumab in patients with KRAS-mutated non–small cell lung cancer (NSCLC) with high PD-L1 expression. The results demonstrated “encouraging preliminary activity.” ....

Marina Chiara Garassino , Fiona Blackhall , University Of Chicago , University Of Manchester , University Of Chicago Marina Garassino , Marina Garassino , Tumor Proportion Score , Esmo Congress , Non Small Cell Lung Cancer ,

Addition of Adjuvant Abemaciclib Reduces Recurrence at 5 Years in HR+, HER2– High-Risk Early Breast Cancer

Results of the monarchE study showed patients with hormone receptor–positive (HR+), HER2-negative (HER2–) high-risk, early breast cancer had greater benefit after 5 years when receiving adjuvant abemaciclib plus endocrine therapy vs endocrine therapy alone. ....

Klinikum Nadia Harbeck , Nadia Harbeck , Breast Center , University Hospital , Esmo Congress , Breast Cancer ,

Lutetium Lu 177 Vipivotide Tetraxetan Plus Enzalutamide Elicits PSA-PFS Improvement in mCRPC

Treatment with the combination of lutetium Lu 177 vipivotide tetraxetan and enzalutamide led to an improvement in prostate-specific antigen progression-free survival vs enzalutamide alone in patients with metastatic castration-resistant prostate cancer. ....

New South Wales , Louise Emmett , Esmo Congress , Lutetium Lu 177 Vipivotide Tetraxetan ,