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Moffitt Cancer Center researchers have revealed that the creation of an immunosuppressive environment is key to the progression of benign colorectal adenomas to
Interactions between cells of the immune system and pre-cancerous cells are known to be important contributing factors to the initiation and progression of cancer.
Tissue architecture impacts the evolutionary course of cancer Tumors are genetically diverse with different mutations arising at different times throughout growth and development. Many models have tried to explain how genetic heterogeneity arises and what impact these alterations have on tumor growth. In a new article published in Nature Communications, Moffitt Cancer Center researchers show how the location of the tumor and spatial constraints put on it by the surrounding tissue architecture impact genetic heterogeneity of tumors. Genetic differences are apparent among tumors from different...
Credit: Moffitt Cancer Center TAMPA, Fla. -- Tumors are genetically diverse with different mutations arising at different times throughout growth and development. Many models have tried to explain how genetic heterogeneity arises and what impact these alterations have on tumor growth. In a new article published in Nature Communications, Moffitt Cancer Center researchers show how the location of the tumor and spatial constraints put on it by the surrounding tissue architecture impact genetic heterogeneity of tumors. Genetic differences are apparent among tumors from different patients, as we...