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Novel brain-permeable Cdk5 inhibitor alters neurobehavior in mice - Vimarsana News

Novel brain-permeable Cdk5 inhibitor alters neurobehavior in mice

Published: May 23, 2022

James Bibb, Ph.D., and colleagues have described a novel preclinical drug that could have the potential to combat depression, brain injury and diseases that impair cognition. The drug, which notably is brain-permeable, acts to inhibit the kinase enzyme Cdk5.

Source: news-medical.net
Related Topics:
United StatesFlorian PlattnerSarbjit SinghAyanabha ChakrabortiJames BibbEmily HendersonYogesh SonawaneJayapal Reddy MallareddyEdwardp AcostaAlan UmfressAmarnath NatarajanKevinj RyanResearch StrategiesUniversity Of Nebraska Medical CenterDepartment Of PharmacologyBirmingham DepartmentMedicine DepartmentNeuro Research StrategiesNebraska Medical CenterLzheimer 39s DiseaseHead TraumaArkinson 39s Disease
Drug Compound Targets Signaling Regulator and Reduces Anxiety-Like Behavior in Mice - Vimarsana News

Drug Compound Targets Signaling Regulator and Reduces Anxiety-Like Behavior in Mice

Published: May 23, 2022

Researchers have developed a brain-permeable compound (25-106) that targets a signaling regulator in brain neurons. The team notes that when the new compound was administered to mice, it could alter their neurobehavior and reduce anxiety-like behavior.

Source: technologynetworks.com
Related Topics:
United StatesFlorian PlattnerSarbjit SinghAyanabha ChakrabortiJames BibbYogesh SonawaneJayapal Reddy MallareddyEdwardp AcostaAlan UmfressAmarnath NatarajanKevinj RyanUniversity Of Alabama At Birminghamdepartment SurgeryResearch StrategiesUniversity Of Nebraska Medical CenterDepartment Of PharmacologyMedicine DepartmentNeuro Research StrategiesNebraska Medical Center