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"Gabapentin for Pain in Pediatric Palliative Care" by Ross Drake, Grace Prael et al.

Objective: Gabapentin is commonly used to treat pain in children receiving pediatric palliative care. This study describes the real-world use of gabapentin and the associated benefits and adverse effects/events (AEs). Methods: A prospective, multicenter cohort of standardized data collection after a clinical decision was made to use gabapentin for managing neuropathic or nociplastic pain in children attended on by a pediatric palliative care service. It was conducted across 11 sites in seven countries including hospital, inpatient, and outpatient services. Clinical outcomes were graded using pain scales validated for age and cognitive ability and the National Cancer Institute Common Terminology Criteria for Adverse Events (NCICTCAE) at baseline, 14 days, 28 days, six weeks and 12 weeks after initiation of gabapentin. Ad-hoc safety reporting continued throughout the study. Results: Data were collected from 127 children with a median age of 4.7 years (IQR 0.1–17.9); 61% had a neurological disorder, 21% advanced cancer and the cohort had a high level of disability (Lansky/Karnofsky performance score 37.1). Gabapentin was prescribed at standard pediatric doses. On average, 76% of children had a reduction in pain and 42% experienced a potential AE. The mean pain score decreased from 6.0 (SD 2.6) at baseline to 3.3 (SD 2.4) at 14 days and 1.8 (SD 1.8) after 12-weeks of gabapentin therapy. Ten percent had increased pain at each time point. AEs did not increase when individual changes over time were accounted for except for somnolence (7%). Serious AEs attributable to gabapentin were possible or probable in 3% of children. Conclusions: Gabapentin prescribed at standard doses for advanced cancer and severe neurological injury in children under a pediatric palliative care service was associated with generally improved pain intensity at previously described levels of adverse effects.

Lansky-karnofsky , Adverse-events , Gabapentin , Ain , Ediatric-palliative-care , Uality-improvement ,

Charges against caretaker for deaths of infant girl, dog in hot car upgraded to murder

The caretaker arrested after an infant and a dog died in a hot car is back in jail and charged with murder.The York-Poquoson Sheriff’s Office in Virginia got ca

Virginia , United-states , Kristen-danielle-graham , York-poquoson-sheriff-office , York-poquoson-sheriff , Law-crime , Gabapentin , Poquoson , Irginia , Sheriffs-in-the-united-states , Law-enforcement-in-the-united-states

Bristol man admits to possessing an uploading child porn, authorities say

A Bristol, Tennessee, man who admitted to possessing and uploading child pornography has been charged, according to the Sullivan County Sheriff's Office.

Tennessee , United-states , Sullivan-county , David-booher , Aaron-witt , National-center , Sullivan-county-sheriff-office , Google , Sullivan-county-sheriff , Exploited-children , Fentanyl , Bristol

Gabapentinoid Use in COPD Associated With Increased Severe Exacerbation Risk, Study Says

Gabapentinoid use, namely gabapentin and pregabalin, was associated with increased risk for severe chronic obstructive pulmonary disease (COPD) exacerbation in patients with epilepsy, neuropathic pain, and other chronic pain.

Canada , Quebec , United-states , America , American , Christel-renoux , Alvi-rahman , International-classification-of-diseases , Mcgill-university , North-america , American-journal , Image-credit

Not exactly a 'car burglary in progress' but it led to a man's 3rd arrest in 10 months

Somebody called the police to report a "car burglary in progress." That wasn't exactly accurate, but the call ended with a man's third arrest in 10 months.

Florida , United-states , Ford-ranger , Michael-griffin-fielder , Gabapentin , Law-crime , Attention-deficit-hyperactivity-disorder-management , Sympathomimetics , Legal-status-of-methamphetamine , Phenethylamines , Methamphetamine

Canyon Lake duo nabbed in major narcotics bust: Fentanyl, meth and more found

NEW BRAUNFELS, Texas —The Comal County Sheriff’s Office arrested two Canyon Lake residents, Tara Lynn Delegram and Kevin Jordan Perez, of illegal possession of

Comal-county , Texas , United-states , Canyon-lake , Tara-lynn-delegram , Comal-county-sheriff-office , Comal-county-sheriff , Kevin-jordan-perez , Valley-view-street , Fentanyl , Law-crime

Unraveling Oklahoma's opioid crisis: New law aims to balance pain management with addiction risks

The understanding of opioid medication has evolved over the past decade and as legislators and medical professionals learn more about the drug the laws and guid

Oklahoma , United-states , Jamison-keefover , Mark-lennihan , Health-medical-pharma , Tulsa , Fox , Kaiser-family-foundation , Cori-loomis , Diane-heaton , Lidocaine

Woman faces charges after baby and dog die in hot car while she sleeps

A baby and a dog are both dead after the woman watching them left them in the car for hours as she went to sleep inside.

Cnn , Family-photos , All-photos , Virginia , United-states , Norfolk , Human-interest , Hospitality-recreation , Law-crime , Gabapentin , Ron-montgomery

'Gut Instinct' Cause for Numerous Sensory Symptoms in Long COVID, Doctors Offer Comprehensive Treatment

'Gut Instinct' Cause for Numerous Sensory Symptoms in Long COVID, Doctors Offer Comprehensive Treatment
theepochtimes.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from theepochtimes.com Daily Mail and Mail on Sunday newspapers.

Wuhan , Hubei , China , Japan , Japanese , Gabapentin , Nattokinase , Diane-counce , Peter-mccullough , Douglas-kell , Resia-pretorius , Keith-berkowitz

Personalizing FM Treatment

Experts discuss how they personalize treatments for patients with fibromyalgia (FM) and the importance of improving sleep in their approach.

Kostas-botsoglou , Wendy-wright , Daniel-clauw , Benjamin-natelson , Fibromyalgia , Cyclobenzaprine , Gabapentin , Milnacipran , Duloxetine ,