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Gene Therapy Shows Potential for Repairing Damage Caused by Glaucoma and Dementia

Gene Therapy Shows Potential for Repairing Damage Caused by Glaucoma and Dementia Source: Science photo library-ktsdesign/Getty Images April 1, 2021 Share Research by scientists at the University of Cambridge has demonstrated how gene therapy might help to repair some of the damage caused by chronic neurodegenerative conditions such as glaucoma and dementia. Their studies in rodents demonstrated how delivering two genes simultaneously using a single vector stimulated axonal transport in a humanized tauopathy model of Alzheimer’s disease, and in an experimental glaucoma model. Encouragingly, the results, reported in Science Advances, showed “promising evidence” that the gene therapy might result in improvement in short-term memory in the tauopathy model of dementia. The team said the studies also highlight the potential effectiveness of gene therapy for treating complex polygenic conditions that have no single genetic cause.

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