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Pulmonary microbiome and gene expression signatures differentiate lung function in pediatric hematopoietic cell transplant candidates

Pulmonary microbiome and gene expression signatures differentiate lung function in pediatric hematopoietic cell transplant candidates
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United States , Chan Zuckerberg Biohub , American Thoracic Society European Respiratory , Allen Co , American Thoracic Society Foundation Grant , Jazz Pharmaceuticals , Alexion Inc , Boehringer Ingelheim , Global Lung Function Initiative , Citius Pharmaceuticals , Omeros Corp , Northern European , Using Global Lung Index , Gene Sets , Molecular Signatures , Human Lung Cell Atlas , Apical Surface , American Thoracic , European Respiratory Society , Institutional Review Board , Supplementary Materials , Supplementary Materials Methods , Hallmark Gene Sets , Molecular Signatures Database , Bluebird Bio , Orchard Therapeutics ,

Frontiers | Chronic Obstructive Pulmonary Disease Patients Have Increased Levels of Plasma Inflammatory Mediators Reported Upregulated in Severe COVID-19

2Informatic Unit, INMEDIT SAS and Faculty of Engineering, University of Cartagena, Cartagena, Colombia
3Clinica Respiratoria y de Alergias, Cartagena, Colombia
4Departamento de Investigaciones, Fundación Cardioinfantil, Bogotá, Colombia
5Research Department - CINEUMO, Fundación Neumológica Colombiana, Bogotá, Colombia
6Research Department and Specialization Program in Pulmonology, Universidad de la Sabana, Bogotá, Colombia
Background: Chronic obstructive pulmonary disease (COPD) is associated with increased risk of severe COVID-19, but the mechanisms are unclear. Besides, patients with severe COVID-19 have been reported to have increased levels of several immune mediators.
Methods: Ninety-two proteins were quantified in 315 plasma samples from 118 asthmatics, 99 COPD patients and 98 healthy controls (age 40-90 years), who were recruited in Colombia before the COVID-19 pandemic. Protein levels were compared between each disease group and healthy contro ....

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