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COVID-19 cases in summer 2020 was not as low as previously thought, new genome-based model suggests Many have attributed the low number of coronavirus disease 2019 (COVID-19) cases in the summer of 2020 to hot weather or increased outdoor activities. But a new study from researchers in Germany suggests this might not have been the case. The results obtained from a genome-based computational pipeline called GInPipe use only time-stamped sequencing data, suggesting some European countries had a large number of undetected COVID-19 cases during this period. Their findings suggest GInPipe could he...

Recent research published on the medRxiv* server has developed a portable, magnetofluidic cartridge platform, for automated PCR testing in <30 min, for rapid multiplexed screening of pathogens. A multidisciplinary team of researchers at Johns Hopkins University and the Johns Hopkins University School of Medicine developed these cartridges for multiplexed detection of SARS-CoV-2 with distinctive variant mutations or with Influenza A and B.

Scientists find dramatic differences between ancient gut microbiomes and modern microbes Scientists are rapidly gathering evidence that variants of gut microbiomes, the collections of bacteria and other microbes in our digestive systems, may play harmful roles in diabetes and other diseases. Now Joslin Diabetes Center scientists have found dramatic differences between gut microbiomes from ancient North American peoples and modern microbiomes, offering new evidence on how these microbes may evolve with different diets. The scientists analyzed microbial DNA found in indigenous human paleofeces ...

Researchers identify new immunotherapy treatment target for acute myeloid leukemia in children Researchers have identified a gene expressed in children with acute myeloid leukemia (AML) that could serve as a new immunotherapy treatment target, according to a new study published today in Blood Advances, a journal of the American Society of Hematology. The study, co-authored by researchers with Nemours Children's Health System, outlines the process and potential path for new immunotherapy drugs that improve survival and reduce treatment-related toxicity in children with AML. Leukemia is the mo...

A new SARS-CoV-2 variant (HMN.19B) has been identified in France New research published in the Centers for Disease Control and Prevention’s journal Emerging Infectious Diseases has confirmed the emergence of a new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant called HMN.19B from the viral clade 19B in France. The 19B viral clade — which includes the D614G variant — was prevalent in late 2019 but had since been rarely observed since early 2020 because of newer viral clades. The variant is characterized by 18 amino acid mutations — including N501Y, L452R, and H65...