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Brain Tumors Incited by Blood Stem Cells

Brain Tumors Incited by Blood Stem Cells
June 28, 2021
A positive link has been found between tumor-associated blood stem cells and glioblastoma progression. This link is supported by evidence from experiments in which blood stem cells were co-cultured with tumor organoids. (The fluorescently labeled tumor organoids in this image were grown from patient cells.) In these experiments, the blood stem cells were shown to promote glioblastoma cell proliferation and PD-L1 expression. [K. Stratmann and C. Dobersalske, German Cancer Research Center]
Glioblastomas are more inclined to dig in and spread out if they are egged on by hematopoietic stem cells. To “dig in,” the glioblastomas become more immunosuppressive. To “spread out,” they support the proliferation of cancer cells, promoting malignancy. The connection between immunosuppressive/malignant glioblastomas and blood stem cells was discovered by scientists affiliated with the German Cancer Consortium (DKTK). The ....

Baden Wüberg , West German , Igor Cima , Nature Communications , German Cancer Consortium , University Hospital Essen Of Duisburg , German Tumor Center , Heidelberg University Hospital , German Cancer Center , German Cancer Research Center , West German Tumor Center , University Hospital , West German Cancer Center , மேற்கு ஜெர்மன் , இயற்கை தகவல்தொடர்புகள் , ஜெர்மன் புற்றுநோய் கூட்டமைப்பு , ஹைடெல்பெர்க் பல்கலைக்கழகம் மருத்துவமனை , ஜெர்மன் புற்றுநோய் மையம் , ஜெர்மன் புற்றுநோய் ஆராய்ச்சி மையம் , பல்கலைக்கழகம் மருத்துவமனை , மேற்கு ஜெர்மன் புற்றுநோய் மையம் ,

Blood stem cells make brain tumors more aggressive

Blood stem cells make brain tumors more aggressive
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Baden Wüberg , West German , Anita Steinbach , Celia Dobersalske , Shruthi Prasad , Vivien Ullrich , Martin Glas , Igor Cima , Sarah Teuber Hanselmann , Jenst Siveke , Tobias Blau , German Consortium For Translational Cancer Research , National Center , Nature Communications , German Cancer Consortium , German Cancer Research Center Deutsches Krebsforschungszentrum , German Tumor Center , Cancer Information Service , Helmholtz Association Of German Research Centers , Department Of Neurosurgery At Essen University Hospital , Heidelberg University Hospital , German Cancer Research Center , Hopp Children Tumour Center Ki , German Centers For Health Research , Ministry Of Education , Translational Oncology ,