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Brain Tumors Incited by Blood Stem Cells

Brain Tumors Incited by Blood Stem Cells
June 28, 2021
A positive link has been found between tumor-associated blood stem cells and glioblastoma progression. This link is supported by evidence from experiments in which blood stem cells were co-cultured with tumor organoids. (The fluorescently labeled tumor organoids in this image were grown from patient cells.) In these experiments, the blood stem cells were shown to promote glioblastoma cell proliferation and PD-L1 expression. [K. Stratmann and C. Dobersalske, German Cancer Research Center]
Glioblastomas are more inclined to dig in and spread out if they are egged on by hematopoietic stem cells. To “dig in,” the glioblastomas become more immunosuppressive. To “spread out,” they support the proliferation of cancer cells, promoting malignancy. The connection between immunosuppressive/malignant glioblastomas and blood stem cells was discovered by scientists affiliated with the German Cancer Consortium (DKTK). The ....

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New Drug Effective Against Lung Cancers Caused by Common Genetic Error

/PRNewswire/ A new drug reduced tumor size in patients who have lung cancer patients with a specific, disease-causing change in the gene KRAS, a study found.. ....

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Novel Antibody Shows Benefit in Cold Agglutinin Disease

Apr 8, 2021
Treatment increased hemoglobin, decreased fatigue
Results from a small open-label trial suggested that treatment with an investigational humanized monoclonal antibody may be an effective treatment for cold agglutinin disease, a rare autoimmune hemolytic anemia for which there are no approved therapies.
The 26-week, single-group trial tested intravenous sutimlimab in 24 cold agglutinin patients who had recently undergone transfusions and found infusions of the antibody halted hemolysis, increased hemoglobin levels, and reduced fatigue in more than half of patients.
The composite primary endpoint was a “normalization of hemoglobin level to 12 g or more per deciliter or an increase in hemoglobin level of 2 g or more per deciliter from baseline, without red-cell transfusion or medications prohibited by protocol,” Alexander Röth, MD, of the West German Cancer Center, University Hospital Essen, University of Duisburg-Essen in Essen, Germany, and colleagu ....

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Activ Surgical Welcomes Prof. Dr. Rainer Kimmig to its European Advisory Board

Activ Surgical Welcomes Prof. Dr. Rainer Kimmig to its European Advisory Board
BOSTON and ESSEN, Germany, Feb. 16, 2021 /PRNewswire/
Activ Surgical, a digital surgery pioneer, today announced the appointment of Prof. Dr. Rainer Kimmig to its European Advisory Board. Prof. Dr. Kimmig currently serves as the department head of Gynecology and Obstetrics at the West German Cancer Center at the University Hospital Essen, Germany, as well as the Chair and full professor at the University of Duisburg-Essen. In his role on Activ Surgical s European Advisory Board, Prof. Dr. Kimmig will collaborate with his peers from leading hospital systems across the European Union (EU) to advise on the company s go-to-market efforts for its products, including ....

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