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New concept drug hunts down late-stage prostate cancer


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A new class of drug successfully targets treatment-resistant prostate cancers and prolongs the life of patients. The treatment delivers beta radiation directly to tumour cells, is well tolerated by patients and keeps them alive for longer than standard care, found a phase 3 trial to be presented at the European Association of Urology congress, EAU21, today.
Despite progress in medicine in recent years, metastatic castration-resistant prostate cancer remains untreatable and fatal. The new treatment, known as Lu-PSMA-617, takes a new approach, targeting a molecule called PSMA, which is known to be increased on the surfaces of the tumour cells, destroying them and their surrounding microenvironment. ....

City Of , United Kingdom , Peter Albers , Ken Herrmann , National Institute For Health , European Association Of Urology , Scientific Office , Institute Of Cancer Research , Head Of The Department Urology , Dusseldorf University , European Association , Johann De Bono , Experimental Cancer Medicine , Cancer Research , Consultant Medical Oncologist , Royal Marsden , Professor Ken Herrmann , Nuclear Medicine , University Hospital Essen , National Institute , Care Excellence , Professor Peter Albers , நகரம் ஆஃப் , ஒன்றுபட்டது கிஂக்டம் , பீட்டர் ஆல்பர்ஸ் , கேன் ஹெர்மன் ,

Measuring the effects of radiotherapy on cancer may open up avenues for treatment


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Ionizing radiation is used for treating nearly half of all cancer patients. Radiotherapy works by damaging the DNA of cancer cells, and cells sustaining so much DNA damage that they cannot sufficiently repair it will soon cease to replicate and die. It s an effective strategy overall, and radiotherapy is a common frontline cancer treatment option. Unfortunately, many cancers have subsets of cells that are able to survive initial radiotherapeutic regimens by developing mechanisms that are able to repair the DNA damage. This often results in resistance to further radiation as cancerous growth recurs. But until recently, little was known about exactly what happens in the genomes of cancer cells following radiotherapy. ....

Emre Kocakavuk , Floris Barthel , Roel Verhaak , Jackson Laboratory , University Hospital Essen , Professor Roel Verhaak , Nature Genetics , புளோரிஸ் பார்தெல் , ஜாக்சன் ஆய்வகம் , பல்கலைக்கழகம் மருத்துவமனை எஸெந் , இயற்கை ஜெநெடிக்ஸ் ,