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Why some melanoma patients do not respond to immunotherapy


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NEW YORK, NY (March 1, 2021) By harnessing the immune system against cancer, immunotherapies have revolutionized the way some types of cancer are treated. But most patients across cancer types do not respond, and in most cases, scientists are at a loss as to why.
Researchers at Columbia and MIT have created a new technique that can uncover nearly all of the tricks cancer cells use to evade immunotherapies, which could lead to the development of more effective treatments.
The researchers tested their new technique with cancer cells and matching immune cells from melanoma patients and identified previously unknown resistance mechanisms to immune checkpoint inhibitors, a powerful and widely used class of immunotherapy drugs. ....

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Theragnostics Announces a research collaboration with Essen University Hospital to study THG-008 for Oncology PET Imaging


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LONDON, Feb. 17, 2021 /PRNewswire/  Theragnostics, which is developing molecular radiotherapy for imaging and treating a broad range of cancers, today announces a research collaboration with Essen University Hospital to examine Theragnostics investigational agent THG-008 for PET imaging in a range of cancers.
The research is due to start in February 2021 and will be led by Dr. Michael Nader, head of radiochemistry and part of the Clinic for Nuclear Medicine at Universitätsklinikum Essen (University Hospital Essen), in Germany.
THG-008 is a novel fluorine-18 radiolabelled PARP inhibitor (
18F-PARPi) which has a number of applications relevant to imaging cancer. A Phase 1 clinical study for THG-008 in head and neck squamous cell carcinoma (HNSCC) completed recruitment in May 2019. Data published in a peer-reviewed publication confirmed imaging of head and neck cancer with  ....

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"Silent" Mutation Linked to Worse Kidney Cancer Outcome | The Scientist Magazine®


For decades, researchers have viewed synonymous mutations as inconsequential quirks of the genome. Due to the way the genetic code is set up where multiple three-base-pair codons can encode the same amino acid mutations can arise that don’t change a protein’s amino acid sequence. Scientists have largely dismissed these anomalies as harmless oddities.
But like other historically underappreciated aspects of the genome, scientists are realizing that many “silent” mutations might not be so silent after all. Research suggests they’re often subject to selective pressure and could play a role in cancer, autism, and schizophrenia.
A study published online last week (February 12) in ....

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Activ Surgical Welcomes Prof. Dr. Rainer Kimmig to its European Advisory Board


Activ Surgical Welcomes Prof. Dr. Rainer Kimmig to its European Advisory Board
BOSTON and ESSEN, Germany, Feb. 16, 2021 /PRNewswire/
Activ Surgical, a digital surgery pioneer, today announced the appointment of Prof. Dr. Rainer Kimmig to its European Advisory Board. Prof. Dr. Kimmig currently serves as the department head of Gynecology and Obstetrics at the West German Cancer Center at the University Hospital Essen, Germany, as well as the Chair and full professor at the University of Duisburg-Essen. In his role on Activ Surgical s European Advisory Board, Prof. Dr. Kimmig will collaborate with his peers from leading hospital systems across the European Union (EU) to advise on the company s go-to-market efforts for its products, including ....

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