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The effect of combined doxorubicin and β-elemene on the proliferation, apoptosis, and oxidative stress levels of doxorubicin-resistant osteosarcoma cells.

Excessive inflammation is a characteristic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, particularly in patients that are hospitalized with coronavirus disease 2019 (COVID-19). Here, Hoepel et al. investigated how human antibodies specific to SARS-CoV-2 spike protein may contribute to exacerbated inflammation. The authors found that spike protein–specific antibodies from patients with COVID-19 who were hospitalized had altered glycosylation, with an enrichment in low-fucosylated antibodies. These antibodies were able to activate human macrophages in vitro to sec...

Many researches have investigated the functions of tetramethylpyrazine (TMP) in Alzheimer disease (AD).

CircRNA-TBC1D4, circRNA-NAALAD2 and circRNA-TGFBR3: selected key circRNAs in neuroblastoma and their associations with clinical features

8 Cytokines, including Il-1β, TNF-α, and PEG 2 and VEGF, have been certified to play an important role in DED, and by inhibiting expression of those cytokines, symptoms of DED could be significantly alleviated. 35–39 Traditional anti-inflammatory agents like corticosteroids would result in disastrous incidence if inappropriately applied, including intraocular hypertension and cataract, 10 which narrows its use in DED therapy. Therefore, an effective anti-inflammation agent with less impact on intraocular pressure is worthy of exploration. Tet, a plant alkaloid isolated from a traditional ...