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UCD opens clinic for treatment-resistant depression

UCD opens clinic for treatment-resistant depression
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United States , Debra Kahn , Katharine Marder , Helenc Kales , Uc Davis Department Of Psychiatry , Uc Davis Health , Department Of Psychiatry , Behavioral Sciences , Uc Davis Medical Center , Care Center , Advanced Psychiatric Therapeutics Clinic , Ambulatory Care Center , Cannery Business Park , East Sacramento ,

New treatments for Alzheimer's disease

Blazing trails or the road to nowhere?

Donanemab is a new monoclonal antibody treatment that binds to amyloid β to stimulate microglial removal of amyloid plaques from the brain in people with Alzheimer’s disease.1 In the recently published Trailblazer-ALZ 2 trial in 1736 adults with early symptomatic disease, participants treated with donanemab had a mean decline over 18 months that was 3.03 points less than those given placebo on a 144 point scale of cognition and functional ability (integrated Alzheimer disease rating scale (−6.02 v −9.27; difference 3.25, 95% confidence interval 1.88 to 4.62). All participants had evidence of brain amyloid and tau protein accumulation on positron emission tomography at recruitment.2 Of a further 24 secondary and exploratory trial outcomes, 23 showed statistically significant benefits with donanemab. Notably, the benefit on the mini-mental state examination was 0.48 points; patients with Alzheimer’s disease dementia typically show an ....

Joep Tupin , Robert Howard , Helenc Kales ,