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#VisualAbstract: Imetelstat improves blood transfusion independence in lower-risk myelodysplastic syndromes

1. Significantly more patients in the imetelstat group achieved RBC transfusion independence at 8 weeks after treatment compared to placebo. 2. Grade 3-4 treatment-related adverse events were greater in the imetelstat group. Evidence Rating Level: 1 (Excellent) Study Rundown: Patients with red blood cell transfusion-dependent lower-risk myelodysplastic syndromes (LR-MDS) face unmet medical needs when unresponsive to erythropoiesis-stimulating ....

Blood Transfusion , Erythropoeisis Stimulating Agents Esas , Febrile Neutropenia , Myelodysplastic Syndrome , Myelodysplastic Syndromes ,

Novel prophylactic anticoagulation scoring tool helps stratify patients following lower limb trauma

1. The 3-month symptomatic venous thromboembolism rate was 0.7% in patients with TRiP(cast) score < 7 and not receiving anticoagulation. 2. There was no significant difference between the control and intervention phases regarding secondary outcomes. Evidence Rating Level: 1 (Excellent) Study Rundown: Venous thromboembolism (VTE) is a well-recognized potential complication resulting from orthopedic trauma and ....

Rating Level , Thrombosis Risk Prediction , Cast Immobilization , Low Molecular Weight Heparin , Between Jun , Oral Anticoagulation , Lower Limb Injury , Lower Limb Trauma , Prophylactic Anticoagulation , Trip Cast Score , Venous Thromboembolism , Venous Thromboembolism Vte , Chronic Disease , Orthopedic Surgery ,

#VisualAbstract: Iptacopan improves hematologic and clinical outcomes in paroxysmal nocturnal hemoglobinuria

1. In two clinical trials, iptacopan in patients with paroxysmal nocturnal hemoglobinuria (PNH) improved hemoglobin levels compared to anti-C5-treated patients and those without complement inhibitors. 2. Patients who received iptacopan generally exhibited improved secondary outcomes, including less fatigue, reduced reticulocyte and bilirubin levels, and decreased breakthrough hemolysis. Evidence Rating Level: 1 (Excellent) Study Rundown: PNH is a ....

Paroxysmal Nocturnal Hemoglobinuria ,