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A single base-resolution sequencing methodology that sequences the two most common cytosine modifications in a single workflow

Researchers developed a WGS method that read four canonical DNA bases, viz., adenine (A), cytosine (C), guanine (G), and thymine (T) plus 5mC and 5hmC, epigenetic variants of unmodified C to yield an accurate six-letter digital readout in a single workflow. ....

Lab Diagnostics , Nature Biotechnology , Automation Industry Focus , Image Credit , Illumina Novaseq , Burrows Wheeler Aligner Minimal , Na Methylation , Ene Expression , High Throughput Sequencing , Ammalian Dna ,

MGI's DNBSEQ-T7* facilitates ultra-deep sequencing of high-complexity metagenomic samples

Thanks to high-throughput sequencing technologies, shotgun metagenomic methods were made possible and had effectively transformed microbiology. Today, advances in both short- and long-read technologies are overcoming many of the previous challenges affecting metagenomic profiling, especially of highly complex samples and environment. ....

United States , Hong Kong , United Kingdom , Czech Republic , Emily Magee , Mathieu Almeida , France National Research Institute For Agriculture , National Research Institute , Nature Portfolio , Scientific Data , Senior Author , Research Fellow , High Throughput Sequencing ,