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PHOTO ABOVE ARTICLE: Artery sections with glowing green smooth muscle cells from a healthy mouse with no atherosclerosis (left) and from a mouse with atherosclerosis (right). The red/purple fluorescence in the atherosclerotic plaque marks cells with DNA damage. (image courtesy of Huize Pan, PhD) The fatty plaques that build up inside arteries in the disease atherosclerosis have features in common with tumors. In a study published April 30 in the journal Circulation, researchers demonstrat ...

<p>Researchers have discovered that the smooth muscle cells that line the arteries of people with atherosclerosis can change into new cell types and develop traits similar to cancer that worsen the disease. Atherosclerosis is characterized by a narrowing of arterial walls and can increase risk of coronary artery disease, stroke, peripheral artery disease, or kidney disorders. The findings, supported by the National Institutes of Health (NIH), could pave the way for the use of anti-cancer drugs to counteract the tumor-like mechanisms driving the buildup of plaque in the arteries, the majo...

A study in Science has tied the aging process to the deterioration of tightly packaged bundles of cellular DNA known as heterochromatinand say that the genetic mutations underlying Werner syndrome, a disorder that leads to premature aging and death, results in the deterioration of these bundles.