Ludwig Cancer Research study shows pancreatic cancer cells reverse to advance malignancy
Credit: Ludwig Cancer Research APRIL 28, 2021, NEW YORK - A Ludwig Cancer Research study has identified a previously unrecognized mechanism by which cancer cells of a relatively benign subtype of pancreatic tumors methodically revert--or "de-differentiate"--to a progenitor, or immature, state of cellular development to spawn highly aggressive tumors that are capable of metastasis to the liver and lymph nodes. The study, led by Ludwig Lausanne's Douglas Hanahan and published in Cancer Discovery, a journal of the American Association for Cancer Research, also shows that engagement of the mech...