Wearable sensors and devices capable of simulating human somatosensation are highly desirable to develop the next generation of electronic skins (e-skins), human-machine interfaces, and soft robotics. Herein, the design of flexible and skin-compliant capacitive pressure sensors for monitoring human motion and physiological signals by electrical signal conversion is reported. The introduction of air chambers into elastomeric polydimethylsiloxane (PDMS) substrate led to the development of pressure sensors with high sensitivity (0.82 kPa−1, up to 20% strain), capable of detecting both static an...