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Study suggests that recall of B cell memory may depend on relative locations of prime and boost immunization

A new study investigated whether a specific population of local Bmem cells in the proximal LNs produce secondary GC responses that are different from those at distal sites and if the location in humoral immunity is relevant only to nonlymphoid tissues. ....

Kateryna Kon Shutterstock , While Bmem , Science Immunology , Influenza Hemagglutinin , B Cell , Immune System , Ars Cov 2 , Evere Acute Respiratory , Evere Acute Respiratory Syndrome ,

CNN CNN Newsroom With Fredricka Whitfield June 4, 2024 16:41:00

Immunizations with the 10 microgram doses, we were seeing declining protection after a few months, both against infection and even though the numbers weren t there in terms of statistical significance, it looks like there was a decrease in the impact on the hospitalization as well. so that third immunization will do what it does for adults which is giving you that neutralized antibody and help you with this much better and it is a good development. and the fourth shot if you ve gotten the double dose of the mrfa. but doctor, is there being research done on vaccines that would stretch them essentially make them longer lasting so that so many boosters are not needed. you point out a really good point. which is that we are seeing declining protection after that third immunization, the first ....

Statistical Significance ,