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mRNA COVID-19 vaccination is immunogenic in the immunocompromised

mRNA COVID-19 vaccination is immunogenic in the immunocompromised
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Research suggests patients who receive COVID-19 vaccines prior to a transplant and subsequent immunosuppression may be protected from the disease.
New research shows that vaccination against SARS-CoV-2 (the virus that causes COVID-19) in immunosuppressed individuals is immunogenic, though to a lesser extent than in the general population.
Two studies in thoracic organ transplantation published in the
Journal of Heart and Lung Transplantation (JHLT) provide the evidence for such a conclusion. Peled
et al. describes 77 vaccinated heart transplant recipients and Havlin
et al. (currently in review) presents 48 vaccinated lung transplant recipients.
Both studies assessed the immunogenicity of Pfizer and BioNTech’s messenger (m)RNA vaccine BNT162b2 mRNA (now marketed as Comirnaty ....

United States , Daniel Goldstein , Lara Danziger Isakov , Eliza Maria Mosher , American Society Of Transplantation , International Transplant Nurses Society , University Of Michigan , Cincinnati Children Hospital Medical Center , Transplantation Society , International Society For Heart , American Society Of Transplant Surgeons , Lung Transplantation , Eliza Maria Mosher Collegiate Professor , Internal Medicine , International Society , Immunocompromised Host Infectious Disease , Cincinnati Children , Hospital Medical Center , American Society , Transplant Surgeons , American Association , Liver Diseases , ஒன்றுபட்டது மாநிலங்களில் , டேனியல் கோல்ட்ஸ்டைன் , எலிசா மரியா மோஷர் , அமெரிக்கன் சமூகம் ஆஃப் மாற்று அறுவை சிகிச்சை ,

ISHLT and JHLT Share COVID-19 Vaccination Findings and Recommendations

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ADDISON, Texas, May 13, 2021 /PRNewswire/ Evidence is emerging about the immunogenicity of vaccination to the SARS-CoV-2 virus in immune-suppressed individuals, including organ transplant recipients. The
Journal of Heart and Lung Transplantation (JHLT) presents two key studies in thoracic organ transplantation.
Peled et al describes 77 vaccinated heart transplant recipients, and Havlin et al presents 48 vaccinated lung transplant recipients. Both of these studies assessed the mRNA vaccine BNT162b2 mRNA (Pfizer/BioNTech). Vaccination was safe with no evidence of short-term allograft-related adverse effects in either cohort. The IgG vaccine-induced antibody response was lower in the transplant patients compared to that reported for the general population, especially in those heart and lung transplant recipients on anti-metabolite immune suppression that contained mycophenolic acid. Havlin et al specifically evaluated T- cell r ....

United States , Danielr Goldstein , Lara Danziger Isakov , Eliza Maria Mosher , American Society Of Transplantation , International Transplant Nurses Society , Cincinnati Children Hospital Medical Center , International Society For Heart , Transplantation Society , American Society Of Transplant Surgeons , University Of Michigan , Eliza Maria Mosher Collegiate Professor , Internal Medicine , Immunocompromised Host Infectious Disease , Cincinnati Children , Hospital Medical , American Society , Solid Organ Transplant , Transplant Surgeons , American Association , Liver Diseases , International Society , Lung Transplantation , The International Society Of Heart And Lung Transplantation , ஒன்றுபட்டது மாநிலங்களில் , எலிசா மரியா மோஷர் ,