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Clinical trial of monoclonal antibody for treating respiratory disease in COVID-19 patients begins


Clinical trial of monoclonal antibody for treating respiratory disease in COVID-19 patients begins
A clinical trial testing the safety and efficacy of an investigational monoclonal antibody for treating people who are hospitalized with respiratory disease and low blood oxygen due to infection with SARS-CoV-2, the virus that causes COVID-19, has begun. The Phase 2 trial, called the COVID-19 anti-CD14 Treatment Trial (CaTT), is sponsored and funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.
The laboratory-created monoclonal antibody, called IC14, binds to a human protein, CD14, that is found on the surface of immune cells circulating in the blood and airway fluid and that also circulates as a stand-alone protein. CD14 helps immune cells recognize pathogens and injured or dying cells, alerting the immune system to danger and prompting it to respond. ....

Vanderbilt University , United States , Foster City , Markm Wurfel , Thomasr Martin , Anthonys Fauci , Emily Henderson , National Institute Of Allergy , National Institutes Of Health , Vanderbilt University In Nashville , Gilead Sciences Inc , Division Of Pulmonary , Tolerance Network , Medicine At University Of Washington , Implicit Bioscience Ltd , National Institute , Infectious Diseases , National Institutes , Critical Care , Sleep Medicine , Immune Tolerance Network , Implicit Bioscience , Gilead Sciences , Respiratory Disease , Clinical Trial , Immune Response ,

NIH trial of anti-CD14 antibody to treat COVID-19 respiratory disease begins


HIN
A clinical trial testing the safety and efficacy of an investigational monoclonal antibody for treating people who are hospitalized with respiratory disease and low blood oxygen due to infection with SARS-CoV-2, the virus that causes COVID-19, has begun. The Phase 2 trial, called the COVID-19 anti-CD14 Treatment Trial (CaTT), is sponsored and funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.
The laboratory-created monoclonal antibody, called IC14, binds to a human protein, CD14, that is found on the surface of immune cells circulating in the blood and airway fluid and that also circulates as a stand-alone protein. CD14 helps immune cells recognize pathogens and injured or dying cells, alerting the immune system to danger and prompting it to respond. ....

Vanderbilt University , United States , Foster City , Markm Wurfel , Thomasr Martin , Anthonys Fauci , National Institute Of Allergy , National Institutes Of Health , Vanderbilt University In Nashville , Gilead Sciences Inc , Division Of Pulmonary , Tolerance Network , Medicine At University Of Washington , Implicit Bioscience Ltd , National Institute , Infectious Diseases , National Institutes , Critical Care , Sleep Medicine , Immune Tolerance Network , Implicit Bioscience , Gilead Sciences , University Of Washington , Vanderbilt University , Infectious Diseases , Immune Response ,