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Management of chronic pain secondary to temporomandibular disorders: a systematic review and network meta-analysis of randomised trials

Objective We explored the comparative effectiveness of available therapies for chronic pain associated with temporomandibular disorders (TMD).

Design Systematic review and network meta-analysis of randomised clinical trials (RCTs).

Data sources MEDLINE, EMBASE, CINAHL, CENTRAL, and SCOPUS were searched to May 2021, and again in January 2023.

Study selection Interventional RCTs that enrolled patients presenting with chronic pain associated with TMD.

Data extraction and synthesis Pairs of reviewers independently identified eligible studies, extracted data, and assessed risk of bias. We captured all reported patient-important outcomes, including pain relief, physical functioning, emotional functioning, role functioning, social functioning, sleep quality, and adverse events. We conducted frequentist network meta-analyses to summarise the evidence and used the GRADE approach to rate the certainty of evidence and categorise interventions from most to least benefic ....

United States , Rodrigo Casassus , Alonso Carrasco , Zijun Li , Matteo Coen , Mina Ma , Naz Torabi , Joannam Zakrzewska , Caroline Samer , Carolyn Palmer , Justin Durham , Labra University Of North Carolina , Chronic Pain Centre Of Excellence , Health Literature , Carolyn Palmer Veterans Affairs Canada , Lanzhou University , David Mock University Of Toronto , Canadian Institutes Of Health Research Canada , Unity Health Toronto , World Bank , Initiative On Methods , Christine Goertz Duke University , Short Form Survey , Randi Mccabe Mcmaster University , Preferred Reporting Items , Cumulative Index ,

Hemp oil, calamari oil and broccoli combined can support chiropractic care to reduce pain

A new double-blind clinical trial indicates supplementation with a novel combination of hemp oil, calamari oil and broccoli can help manage pain intensity, interference and oxidative stress when combined with standard chiropractic care. ....

North Carolina , United States , Initiative On Methods , Spain Assessment , Clinical Trials ,

SpineThera Announces Results for SX600 from its SALIENT Phase 2 Sciatica Pain Clinical Trial Support

PLYMOUTH, Minn. (BUSINESS WIRE) SpineThera, Inc., a privately held, clinical-stage pharmaceutical company focused on the development of SX600 (a novel formulation of extended-release dexamethasone microspheres for transforaminal epidural injection [TF-EI] for the management of sciatica pain) today announced promis. ....

South Australia , United States , University Of Adelaide , Jeff Missling , Clinical Research , Initiative On Methods , Spinethera Inc , Oswestry Disability Index , Spain Assessment , Clinical Trials , Guy Ludbrook , Royal Adelaide Hospital , Acute Care Medicine , Principal Investigator , Bill Houghton , Chief Medical Officer , Medical Director , Medical Alley ,

SpineThera Announces Results for SX600 from its SALIENT Phase 2 Sciatica Pain Clinical Trial Supporting the Potential for Best-In-Class Therapy

SpineThera Announces Results for SX600 from its SALIENT Phase 2 Sciatica Pain Clinical Trial Supporting the Potential for Best-In-Class Therapy
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South Australia , United States , University Of Adelaide , Jeff Missling , Clinical Research , Initiative On Methods , Spinethera Inc , Oswestry Disability Index , Spain Assessment , Clinical Trials , Guy Ludbrook , Royal Adelaide Hospital , Acute Care Medicine , Principal Investigator , Bill Houghton , Chief Medical Officer , Medical Director , Medical Alley ,

Study: The pandemic has worsened the condition of 70% of people with chronic pain

Study: The pandemic has worsened the condition of 70% of people with chronic pain
The pandemic has impacted significantly on people who suffer chronic pain. A study performed by the eHealth Lab, a research group affiliated with the Faculty of Health Sciences and the Universitat Oberta de Catalunya s eHealth Center, has shown that 70% of the people with chronic pain have seen their condition worsen in terms of severity, frequency of episodes and interference in their daily activities.
A total of 502 patients took part in the study; 88% were women aged between 30 and 59, with long-duration chronic pain (mean duration, 7 years). Most participants (87.6%) had pain in more than one point; the most frequent locations were the abdomen, lower back and neck. The participants answered online surveys, designed in accordance with the IMMPACT (Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials) methodology, and the CPGQ (Chronic Pain Grade Questionnaire) was use ....

Universitat Rovirai Virgili , Juan Vicente Luciano Devis , Rebeca Pardo , Beatriz Sora , Albert Feliu Soler , Emily Henderson , Health Lab , Psychology Department , Health Park , Faculty Of Health Sciences , Autonomous University Of Madrid , European University Of Madrid , Research Institute , Health Center , Initiative On Methods , Health Sciences , Universitat Oberta De Catalunya , Spain Assessment , Clinical Trials , Chronic Pain Grade Questionnaire , Universitat Rovira , European University , Autonomous University , Sant Joan , Chronic Pain , Pain Management ,