14 TCAs have cardiac toxicity, and SNRIs have complications related to hypertension. 15,16 Patients should be closely observed when they have these prescriptions. There is no evidence that shows that patients with depression have a reduced risk of CHD with the other antidepressants. Thus, clinical doctors have a great interest in finding a treatment not only for treating depression but also for reducing CHD risk. SSRIs have been recommended by the American Heart Association (AHA) for treating CHD patients with depression because of their safety. 17 Although some studies have shown the effecti...