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Novel protein interactions with ACE2 disrupted by SARS-CoV-2, contributes to COVID-19 pathologies The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused severe morbidity and mortality across the world. Other than flu-like symptoms of respiratory disease, SARS-CoV-2 infection can also cause systemic manifestations, leading to a wide range of pathologies, including thrombosis and microvascular injury and stroke, vascular system disruption, gastrointestinal complications, ocular and dermatological symptoms, cardiac and kidney pathologies, neurological manif...