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Young women carry the highest risk, study finds

Breast cancer survival has improved hugely since 1975. But what is it that has made the difference? Is it screening, the treatment of early stage cancer, or the management of metastatic cancer? And as treatment improves, does screening still have a place? This study used four simulation CISNET models to estimate the relative impact of interventions at each stage. Overall, improvements in mammographic screening and treatment of breast cancer in the US between 1975 and 2019 were associated with a 58% reduction in breast cancer mortality (from an estimated 64 deaths without intervention to 27 per...

Lifetime reduction in acute pain episodes should offset high upfront costs of the therapy

In September, the UK started phasing out use of the live herpes zoster vaccine (Zostavax) to replace it with the recombinant vaccine Shingrix. Vaccination is also gradually being offered to younger people, eventually from the age of 60 years. A phase 3 randomised controlled trial of Shingrix had previously found an efficacy of 97% in adults aged 50 years and above, and a longer duration of protection than from the live vaccine, meaning it could be offered from a younger age. A new observational study of over two million people aged over 50 who have had the recombinant vaccine used diagnostic ...

39% higher risk compared with nonusers, database study finds