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Wars, drought, displacement, and instability are causing a dramatic increase in the number of pregnant and breastfeeding women around the world who suffer from malnutrition.
Researchers have created an
Researchers have created an <i>in vitro</i> human model of environmental enteric dysfunction in a microengineered Intestine Chip device, providing a window into the complex interplay between malnutrition and genetic factors driving the disease.
Millions of children in low- and middle-income nations suffer from environmental enteric dysfunction (EED), a chronic inflammatory disease of the intestine that is the second leading cause of death in children under five years old.
This cross section of a mouse Colon Chip shows the actin cytoskeleton of epithelial cells in magenta, the overlying mucus in yellow, and the cells' nuclei in blue. The team used this chip in a comparative analysis of mouse and human microbiomes to test their different abilities to induce tolerance to the pathogen Salmonella typhimurium. Credit: Wyss Institute at Harvard University Read Time: Trillions of commensal microbes live on the mucosal and epidermal surfaces of the body and it is firmly established that this microbiome affects its hostâs tolerance and sensitivity to a variety...