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Alternative splicing plays a role in compensating for loss of gene function

Living organisms have a knack for persisting in the face of challenges. For instance, when genes malfunction, organisms may be able to compensate by activating redundant genes with similar functions, called paralogs. ....

Larissa Nitschke , Ireneh Fulbright , S Donald Greenberg , Thomasa Cooper , Emily Henderson , Baylor College Of Medicine , Myotonic Dystrophy Type , Baylor College , Greenberg Chair , Industry Focus , Danl Duncan Comprehensive Cancer Center , Dystrophy Type , Spinal Muscular Atrophy , Muscular Dystrophy , Myotonic Dystrophy , Protein Expression ,

Researchers find how to compensate for loss of gene function

Living organisms have a knack for persisting in the face of challenges ....

Larissa Nitschke , Ireneh Fulbright , S Donald Greenberg , Thomasa Cooper , Nucleic Acids Research , Baylor College Of Medicine , Myotonic Dystrophy Type , Baylor College , Greenberg Chair , Nucleic Acids , Danl Duncan Comprehensive Cancer Center , Dystrophy Type , Spinal Muscular Atrophy , Ews India ,

Novel mouse model of myotonic dystrophy displays reversible cardiac disease features of the condition

People with myotonic dystrophy type 1 (DM1), the most common adult-onset form of muscular dystrophy, progressively lose muscle mass and strength in their lower legs, hands, neck and face. The effects of the condition extend to the cardiac and central nervous systems and the gastrointestinal organs.
Human chromosome 19. Gene
DMPK is in the region q13.32. Credit: Genetics Home Reference
The laboratory of Dr. Thomas A. Cooper, professor of pathology and immunology, of molecular and cellular biology and of molecular physiology and biophysics at Baylor College of Medicine, has long been contributing to a better understanding of DM1. In his most current study, he and his colleagues focused on the cardiac aspects of the disease, which affects 50% of DM1 patients and is the second leading cause of mortality in individuals with the condition, after respiratory insufficiency resulting from skeletal muscle wasting. ....

United States , Ashishn Rao , Xanderht Wehrens , Xiangnan Guan , Hannahm Campbell , Ireneh Fulbright , Zheng Xia , Thomas Cooper , S Donald Greenberg , Thomasa Cooper , Oregon Health Science University , Baylor College Of Medicine , Baylor College , Genetics Home Reference , Danl Duncan Comprehensive Cancer Center , Clinical Investigation , Oregon Health , Science University , ஒன்றுபட்டது மாநிலங்களில் , தாமஸ் கூப்பர் , ஓரிகந் ஆரோக்கியம் அறிவியல் பல்கலைக்கழகம் , பேலர் கல்லூரி ஆஃப் மருந்து , பேலர் கல்லூரி , ஜெநெடிக்ஸ் வீடு குறிப்பு , மருத்துவ விசாரணை , ஓரிகந் ஆரோக்கியம் ,