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Pathogens get comfy in designer goo

Pathogens get comfy in designer goo
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Bio-inspired scaffolds help promote muscle growth

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IMAGE: Aligned myotubes formed on electrospun extracellular matrix scaffolds produced at Rice University. The staining with fluorescent tags shows cells expression of myogenic marker desmin (green), actin (red) and nuclei (blue).
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Credit: Mikos Research Group/Rice University
HOUSTON - (May 14, 2021) - Rice University bioengineers are fabricating and testing tunable electrospun scaffolds completely derived from decellularized skeletal muscle to promote the regeneration of injured skeletal muscle.
Their paper in
Science Advances shows how natural extracellular matrix can be made to mimic native skeletal muscle and direct the alignment, growth and differentiation of myotubes, one of the building blocks of skeletal muscle. The bioactive scaffolds are made in the lab via electrospinning, a high-throughput process that can produce single micron-scale fibers. ....

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Researchers demonstrate lab tool that simplifies simulations of the human intestine

Researchers demonstrate lab tool that simplifies simulations of the human intestine
Rice University and Baylor College of Medicine researchers have found a way to mimic conditions in intestines, giving them a mechanical model for the real-time growth of bacterial infections.
In a new study, they demonstrate a lab tool that simplifies simulations of the human intestine, making it more practical to find treatments for diseases like infectious diarrhea.
The team led by bioengineer Jane Grande-Allen of Rice s Brown School of Engineering developed transparent millifluidic perfusion cassettes (mPCs) that are easy to fabricate and operate and compatible with common microscopic and biochemical analysis. ....

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Simple bioreactor makes 'gut check' more practical

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IMAGE: Researchers at Rice University and Baylor College of Medicine developed millifluidic perfusion cassettes (mPCs) that mimic conditions in the intestines to evaluate infections like those that cause diarrhea. The devices.
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Credit: Rice University/Baylor College of Medicine
HOUSTON - (Jan. 7, 2021) - Rice University and Baylor College of Medicine researchers have found a way to mimic conditions in intestines, giving them a mechanical model for the real-time growth of bacterial infections.
In a new study, they demonstrate a lab tool that simplifies simulations of the human intestine, making it more practical to find treatments for diseases like infectious diarrhea. ....

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