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Objective To investigate the association between changes in long term residential exposure to ambient fine particulate matter (PM2.5) and premature mortality in Canada. Design Population based quasi-experimental study. Setting Canada. Participants 663 100 respondents to the 1996, 2001, and 2006 Canadian censuses aged 25-89 years who had consistently lived in areas with either high or low PM2.5 levels over five years preceding census day and moved during the ensuing five years. Interventions Changes in long term exposure to PM2.5 arising from residential mobility. Main outcome measures The primary outcome was deaths from natural causes. Secondary outcomes were deaths from any cardiometabolic cause, any respiratory cause, and any cancer cause. All outcomes were obtained from the national vital statistics database. Results Using a propensity score matching technique with numerous personal, socioeconomic, health, and environment related covariates, each participant who moved to a d

United statesAaron van donkelaarMegan kirby mcgregorJays kaufmanLi baiLauren pinaultHong chenTarik benmarhniaMichael tjepkemaPerry hystadToyib olaniyanLi chenRandallv martinRichardt burnettResearch ethics board of health canadaHealth canada