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Silver Nanoclusters Inhibit DNA Replication


Columbia University Irving Medical Center
Silver nanoclusters-which could be applied to the treatment of cancer in the future-block an early step of DNA replication, a new study by researchers in the Institute for Cancer Genetics at Columbia University Vagelos College of Physicians and Surgeons and the Herbert Irving Comprehensive Cancer Center has found.
Silver nanoclusters, which contain just a few to tens of atoms, are a more recent addition to the collection of silver nanomaterials, including larger-sized silver nanoparticles.
“In the long term, we may be able to harness the toxicity of silver nanoclusters.”
Because of silver nanoclusters’ unique chemical characteristics, they are used in a wide array of applications, including antimicrobial agents and electronics, and are being investigated for use in cancer imaging and drug delivery. ....

Shan Zha , Jamesa Wolff , Kam Leong , Jean Gautier , Mingqiang Li , Kamw Leong , Tomas Aparicio , Samuely Sheng , Yu Tao , National Natural Science Foundation Of China , National Cancer Institute , Guangdong Provincial Pearl River Talents Program , Us National Institutes Of Health , Nucleic Acids Research , Columbia University , Institute For Cancer Genetics , Sun Yat Sen University , Herbert Irving Comprehensive Cancer Center , Cancer Genetics , Columbia University Vagelos College , Nucleic Acids , Associate Professor , National Natural Science Foundation , National Cancer Institute , Conflict Of Interest , Cell Biology ,