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Study provides new insights into the origins of genetic disorders

New insights into the ability of DNA to overcome harmful genetic changes have been discovered by scientists at the Wellcome Sanger Institute, the University of Lausanne and their collaborators. ....

Jolanda Van Leeuwen , Sanger Institute , University Of Toronto , University Of Lausanne , Wellcome Sanger Institute , Molecular Systems Biology , Leopold Parts , Wellcome Sanger , ஜொழந்த வேன் லீவன் , சாங்கர் நிறுவனம் , பல்கலைக்கழகம் ஆஃப் டொராண்டோ , வெல்கம் சாங்கர் நிறுவனம் , மூலக்கூறு அமைப்புகள் உயிரியல் , வெல்கம் சாங்கர் ,

'Rescue mutations' that suppress harmful DNA changes could shed light on genetic disorders

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New insights into the ability of DNA to overcome harmful genetic changes have been discovered by scientists at the Wellcome Sanger Institute, the University of Lausanne and their collaborators. The team found that 26 per cent of harmful mutations were suppressed by naturally occurring variants in at least one wild yeast strain. In each instance examined in detail, a single rescue mutation was responsible for cancelling out another mutation that would have threatened the organism s survival.
The study, published today (27 May 2021) in
Molecular Systems Biology, provides important information about how DNA variants can suppress undesirable genetic changes. If confirmed in humans, this biological phenomenon could have an important role in genetic diseases such as cancer or rare developmental disorders, and explain why certain patients suffer from more severe disease than others. ....

United Kingdom , Jolanda Van Leeuwen , Matthew Midgley , Maykel Lopes , Sanger Institute , Wellcome Sanger Institute , University Of Toronto , Foundation For Medical Research , Swiss National Science Foundation , University Of Lausanne , Molecular Systems Biology , Leopold Parts , Amandine Batt , Molecular Biology , ஒன்றுபட்டது கிஂக்டம் , ஜொழந்த வேன் லீவன் , மேத்யூ மிட்லே , சாங்கர் நிறுவனம் , வெல்கம் சாங்கர் நிறுவனம் , பல்கலைக்கழகம் ஆஃப் டொராண்டோ , அடித்தளம் க்கு மருத்துவ ஆராய்ச்சி , சுவிஸ் தேசிய அறிவியல் அடித்தளம் , மூலக்கூறு அமைப்புகள் உயிரியல் ,