3D analysis of SARS-CoV-2 reveals clues on virus tactics miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.
Lord of the flies, king of data and proud owner of seven bicycles ethz.ch - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from ethz.ch Daily Mail and Mail on Sunday newspapers.
A specific protein complex from plant stem cells regulates their division and response to stress miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.
14 Sep 2021 Metabolic profiling of cell line collections has become an invaluable tool in the study of disease etiology, drug modes of action, and to select personalized treatments. However, large-scale in vitro dynamic metabolic profiling is limited by time-consuming sampling and complex measurement procedures. By combining an high-throughput metabolomics platform developed at the Institute of Molecular Systems Biology of ETH in Zurich with time-lapse microscopy, Dr. Mattia Zampieri has established a workflow for the large-scale metabolic profiling of adherent mammalian cells and the rapid measurement and analysis of drug-induced dynamic changes in intracellular metabolites. In this webinar, Dr. Mattia Zampieri, junior PI at the institute, will illustrate how this technology enables them to study the role of aberrant transcriptional regulation in mediating cancer metabolic rewiring and how it can be applied to reveal drug mechanisms of action. This approach opens new opportunities in systems pharmacology and reveals new ways to analyze patient-derived metabolic profiles and the development of alternative therapeutic strategies to counteract upstream reprogramming of cellular metabolism.
Nautilus Biotechnology Appoints Emma Lundberg, Ph.D., to Scientific Advisory Board biospace.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from biospace.com Daily Mail and Mail on Sunday newspapers.
New insights into the ability of DNA to overcome harmful genetic changes have been discovered by scientists at the Wellcome Sanger Institute, the University of Lausanne and their collaborators.
E-Mail New insights into the ability of DNA to overcome harmful genetic changes have been discovered by scientists at the Wellcome Sanger Institute, the University of Lausanne and their collaborators. The team found that 26 per cent of harmful mutations were suppressed by naturally occurring variants in at least one wild yeast strain. In each instance examined in detail, a single rescue mutation was responsible for cancelling out another mutation that would have threatened the organism s survival. The study, published today (27 May 2021) in Molecular Systems Biology, provides important information about how DNA variants can suppress undesirable genetic changes. If confirmed in humans, this biological phenomenon could have an important role in genetic diseases such as cancer or rare developmental disorders, and explain why certain patients suffer from more severe disease than others.
14 Sep 2021 Metabolic profiling of cell line collections has become an invaluable tool in the study of disease etiology, drug modes of action, and to select personalized treatments. However, large-scale in vitro dynamic metabolic profiling is limited by time-consuming sampling and complex measurement procedures. By combining an high-throughput metabolomics platform developed at the Institute of Molecular Systems Biology of ETH in Zurich with time-lapse microscopy, Dr. Mattia Zampieri has established a workflow for the large-scale metabolic profiling of adherent mammalian cells and the rapid measurement and analysis of drug-induced dynamic changes in intracellular metabolites. In this webinar, Dr. Mattia Zampieri, junior PI at the institute, will illustrate how this technology enables them to study the role of aberrant transcriptional regulation in mediating cancer metabolic rewiring and how it can be applied to reveal drug mechanisms of action. This approach opens new opportunities in systems pharmacology and reveals new ways to analyze patient-derived metabolic profiles and the development of alternative therapeutic strategies to counteract upstream reprogramming of cellular metabolism.
E-Mail Mycobacterium tuberculosis is incredible in that it can survive for decades within its human host. It does this by varying its diet to successfully steal nutrients from the human host including immune cells; it is known to acquire and absorb multiple carbon sources from the body during infection. In a paper published in the journal Molecular Systems Biology, Surrey scientists detail how they measure the flow of metabolites or fluxes through metabolic pathways when Mycobacterium tuberculosis is consuming some of its favourite nutrients. Measuring these fluxes could help scientists advance new tuberculosis drugs as well as understand why the bacterium survives so long in humans and why current antibiotics are often ineffective.