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The Success of the Ice Bucket Challenge and the Failure of the US Government by Daniel Faris Unless you’ve been stranded on an island for the last six months, there’s a good chance that by now you’ve heard of the Ice Bucket Challenge. For those island-dwellers among you, here’s a brief recap: To raise awareness for amyotrophic lateral sclerosis (ALS) – more commonly known as Lou Gehrig’s disease – participants filmed short videos of themselves pouring buckets of ice water on their heads and when all was said and done, they’d challenge three of their friends to do the same – ...

Experimental safety switch reduces severity of CAR-T immunotherapy-related side effects UNC Lineberger Comprehensive Cancer Center researchers have successfully used an experimental safety switch, incorporated as part of a chimeric antigen receptor T-cell (CAR-T) therapy, a type of immunotherapy, to reduce the severity of treatment side effects that sometimes occur. This advance was seen in a patient enrolled in a clinical trial using CAR-T to treat refractory acute B-cell leukemia. It demonstrates a proof-of-principle for possible expanded use of CAR-T immunotherapy paired with the safety sw...

 E-Mail IMAGE: Matthew Foster, MD, and his UNC Lineberger colleagues have used an experimental safety switch incorporated as part of a chimeric antigen receptor-modified T cell therapy (CAR-T) for an aggressive form... view more  Credit: UNC Lineberger Comprehensive Cancer Center CHAPEL HILL, North Carolina--UNC Lineberger Comprehensive Cancer Center researchers have successfully used an experimental safety switch, incorporated as part of a chimeric antigen receptor T-cell (CAR-T) therapy, a type of immunotherapy, to reduce the severity of treatment side effects that sometimes occur...