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Discovery: Faulty DNA Disposal System Linked to Inflammation

Cells in the human body contain power-generating mitochondria, each with their own mtDNA—a unique set of genetic instructions entirely separate from the cell’s nuclear DNA that mitochondria use to create life-giving energy. When mtDNA remains where i

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Inflammation Linked to Faulty DNA Disposal System

Inflammation Linked to Faulty DNA Disposal System
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Faulty DNA disposal system causes inflammatio

<p>Salk scientists discovered a pathway from mitochondrial DNA replication stress to immune system activation and inflammation, finding that endosomes responsible for disposing of dysfunctional mitochondrial DNA were leaking mitochondrial DNA into the cell and prompting the inflammatory immune response. The pathway provides new targets for therapeutics that disrupt inflammation during aging and disease.</p>

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Mitochondrial misfire sparks inflammation

Cells in the human body contain power-generating mitochondria, each with their own mtDNA-;a unique set of genetic instructions entirely separate from the cell's nuclear DNA that mitochondria use to create life-giving energy.

Canada , Gerald-shadel , Ricardo-rodriguez-enriquez , Sagnika-ghosh , Michaela-medina , Gladys-rojas , Laura-newman , Joshua-chevez , Nimesha-tadepalle , Danielle-grotjahn , Audrey-geisel , Cara-schiavon

Faulty DNA disposal system causes inflammation

Faulty DNA disposal system causes inflammation
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Faulty DNA disposal system causes inflammatio

Faulty DNA disposal system causes inflammatio
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Canada , Jonas-salk , Nimesha-tadepalle , Gladys-rojas , Laura-newman , Joshua-chevez , Danielle-grotjahn , Cara-schiavon , Audrey-geisel , Ian-lemersal , Sammy-weiser-novak , Matthew-donnelly