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<p>Salk scientists discovered a pathway from mitochondrial DNA replication stress to immune system activation and inflammation, finding that endosomes responsible for disposing of dysfunctional mitochondrial DNA were leaking mitochondrial DNA into the cell and prompting the inflammatory immune response. The pathway provides new targets for therapeutics that disrupt inflammation during aging and disease.</p>
Cells in the human body contain power-generating mitochondria, each with their own mtDNA-;a unique set of genetic instructions entirely separate from the cell's nuclear DNA that mitochondria use to create life-giving energy.
Salk scientists found that manipulating how cell's produce energy can reduce melanoma tumor growth and enhance immune response in mice. Their findings may be leveraged to create new cancer therapeutics that do not harm mitochondria and cells.
Salk scientists found that manipulating how cell's produce energy can reduce melanoma tumor growth and enhance immune response in mice. Their findings may be leveraged to create new cancer therapeutics that do not harm mitochondria and cells.
During a recent study researchers have discovered how mitochondrial function, and dysfunction, play critical roles in numerous diseases, and even ageing.