Messed-up metabolism during development may lead guts to coil the wrong way
Tadpoles exposed to a metabolism-disrupting herbicide had malformed intestines, providing clues to a human condition called intestinal malrotation.
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Tadpoles exposed to a metabolism-disrupting herbicide had malformed intestines, providing clues to a human condition called intestinal malrotation.
How does our intestine, which can be at least 15 feet long, fit properly inside our bodies? As our digestive system grows, the gut tube goes through a series of
Scientists have identified a possible cause for intestinal malrotation; a common but poorly understood condition present at birth in which the gut doesn't rotate properly during development.
<p>Scientists from North Carolina State University have used a herbicide to discover that disrupting metabolism could derail a series of cellular events required for proper elongation and rotation of the gut in frogs. This new study, published in the journal Development, uncovers a potential mechanism of intestinal malrotation in humans.</p>