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Pyrotinib versus placebo in combination with trastuzumab and docetaxel as first line treatment in patients with HER2 positive metastatic breast cancer (PHILA): randomised, double blind, multicentre, phase 3 trial

Objective To assess the efficacy and safety of pyrotinib (an irreversible pan-HER (human epidermal growth factor receptor) inhibitor), trastuzumab, and docetaxel compared with placebo, trastuzumab, and docetaxel for untreated HER2 positive metastatic breast cancer.

Design Randomised, double blind, placebo controlled, multicentre, phase 3 trial.

Setting 40 centres in China between 6 May 2019 and 17 January 2022.

Participants 590 female patients (median age 52 (interquartile range 46-58) years) with untreated HER2 positive metastatic breast cancer.

Interventions Eligible patients were randomised 1:1 to receive either oral pyrotinib (400 mg once daily) or placebo, both combined with intravenous trastuzumab (8 mg/kg in cycle 1 and 6 mg/kg in subsequent cycles) and docetaxel (75 mg/m2) on day 1 of each 21 day cycle. Randomisation was stratified by treatment history of trastuzumab in the (neo)adjuvant setting and hormone receptor status. Patients, investigators, a ....

Eteläuomen Läi , Pconclusions Pyrotinib , Jiaman Lin Hengrui , Tengfei Zhang , Demets Obrien Fleming , Kaijing Zhao Hengrui , Eastern Cooperative Oncology Group , Human Genetic Resource Administration Of China , Drug Administration , Jiangsu Hengrui Pharmaceuticals , China National Medical Products Administration , Innovation Fund For Medical Sciences , Response Evaluation Criteria , Solid Tumors , National Cancer Institute , Common Terminology Criteria , Adverse Events , Good Clinical Practice , Human Genetic Resource Administration , Jiaman Lin , Kaijing Zhao , Good Publication Practice , Medical Sciences , Jiangsu Hengrui , Open Access , Creative Commons Attribution Non Commercial ,

Coherus rejects 'heavily discounted' pricing on Loqtorzi, the first China-made PD-1 drug to win FDA nod

Coherus rejects 'heavily discounted' pricing on Loqtorzi, the first China-made PD-1 drug to win FDA nod
fiercepharma.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from fiercepharma.com Daily Mail and Mail on Sunday newspapers.

Bristol Myers Squibb Opdivo , Eli Lilly , Coheru Lanfear , Denny Lanfear , Daina Graybosch , Coherus Biosciences , Paul Reider , Merck Co , Coheru Junshi Biosciences Partnered , Bristol Myers Squibb , Innovent Biologics Partnered Tyvyt , Leerink Partners , Fierce Pharma ,

84-year-old man transforms regular bicycle into e-cycle using solar power, ET Auto

Munshi Ram, an 84-year-old resident of Udhampur, Jammu and Kashmir, has transformed a regular bicycle into an eco-friendly E-cycle powered by solar and electricity. Inspired by the Prime Minister s "Vocal for Local" and "Green India" initiatives, he used discarded laptop batteries and e-waste to build his E-cycle. ....

Jammu And Kashmir , Munshi Ram , Prime Minister , 2e Cycle , Munshi Ram , Green India , E Cycle Using Both Solar Energy And Electricity ,

Coherus BioSciences, Inc. (NASDAQ:CHRS) Q2 2023 Earnings Call Transcript

Operator: Good day and thank you for standing by. Welcome to the Coherus Biosciences Second Quarter 2023 Conference Call. At this time all participants are in a listen-only mode. ....

United States , Chris Schott , Theresa Lavallee , Douglas Tsao , Mcdavid Stilwell , Balaji Prasad , Mark Cuban , Marek Ciszewski , Rosh Dias , Robyn Karnauskas , Michael Nedelcovych , Jason Gerberry , Coherus Biosciences , Paul Reider , Denny Lanfear , Neulasta Onpro , Coherus Biosciences Inc , Mark Cuban Cost Plus Drugs Company , Charming Shoppes Inc , Team Cuban Card , American Society Of Retina Specialists , Call Transcript August , Coherus Biosciences Second Quarter , Surface Oncology , Chief Development Officer , Chief Medical Officer ,

FDA flags issues at Coherus partner's China plant for cancer drug

Coherus BioSciences Inc said on Wednesday that the U.S. Food and Drug Administration had flagged three observations at its partner s manufacturing site in China when the agency was conducting. | May 31, 2023 ....

Pooja Desai , Raghav Mahobe , Bhanvi Satija , Shanghai Junshi Biosciences Co Ltd , Rashmi Aich , Coherus Biosciences , Nc Stock Exchange , Press Release , As Chrs Us19249h1032 ,