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'Central dogma' of biology be misleading bioengineers

'Central dogma' of biology be misleading bioengineers
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Citradewi Soemardy , Kathrin Plath , Justin Langerman , Brian Cheng , Shreya Udani , Simran Kang , Doyeon Koo , Partillion Bioscience , Sevana Baghdasarian , Edythe Broad Center , Broad Stem Cell Research Center , Stem Cell Research , California Nanosystems Institute , Samueli School Of Engineering , National Institutes Of Health , Nature Nanotechnology , Dino Di Carlo , Elena Hairapetian Professor , Regenerative Medicine , Stem Cell , Joseph De Rutte , National Institutes , Stem Cell Nanomedicine Planning Award , Broad Stem Cell Research ,

Could the 'central dogma' of biology be misleading bioengineers?

UCLA stem cell scientists find surprise genetic instructions for boosting protein secretion, with big implications for biotechnology and cell therapy. ....

Citradewi Soemardy , Brian Cheng , Sevana Baghdasarian , Shreya Udani , Simran Kang , Partillion Bioscience , Doyeon Koo , Kathrin Plath , Justin Langerman , Broad Stem Cell Research Center , Stem Cell Research , California Nanosystems Institute , Samueli School Of Engineering , National Institutes Of Health , Edythe Broad Center , Nature Nanotechnology , Dino Di Carlo , Elena Hairapetian Professor , Nanosystems Institute , Regenerative Medicine , Stem Cell , Joseph De Rutte , National Institutes , Stem Cell Nanomedicine Planning Award , Broad Stem Cell Research , Stem Cells ,

Molecular analysis identifies key differences in lungs of cystic fibrosis patients

Nature Medicine
Healthy airways (left) show well-defined layers of ciliated cells (green) and basal stem cells (red). In airways affected by cystic fibrosis (right), the layers are disrupted, and scientists identified a transitioning cell type that combines properties of both stem cells and ciliated cells (red and green in the same cell).
A team of researchers from UCLA, Cedars-Sinai and the Cystic Fibrosis Foundation has developed a first-of-its-kind molecular catalog of cells in healthy lungs and the lungs of people with cystic fibrosis.
The catalog, described today in the journal Nature Medicine, reveals new subtypes of cells and illustrates how the disease changes the cellular makeup of the airways. The findings could help scientists in their search for specific cell types that represent prime targets for genetic and cell therapies for cystic fibrosis. ....

Brigitte Gomperts , Barry Stripp , Kathrin Plath , John Jed Mahoney , Gianni Carraro , Justin Langerman , National Cancer Institute , Cystic Fibrosis Foundation , Tumor Cell Biology Training Program , Sinai Board Of Governors Regenerative Medicine Institute , Parkerb Francis Foundation Fellowship , National Heart , Blood Institute , Edythe Broad Center , Stem Cell Research , Cystic Fibrosis Foundation Therapeutics Lab , Broad Stem Cell Research Center , National Institutes Of Health , David Geffen School Of Medicine , Wm Keck Foundation , Disease Research Program , Cystic Fibrosis Foundation Epithelial Stem Cell Consortium , Howard Hughes Medical Institute , Nature Medicine , Regenerative Medicine , Cystic Fibrosis Foundation Therapeutics ,