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UCLA stem cell scientists find surprise genetic instructions for boosting protein secretion, with big implications for biotechnology and cell therapy.

A collaboration led by UCLA and the Seattle Children's Research Institute has yielded new knowledge about the genes responsible for the production and release of immunoglobulin G, the most common type of antibody in the human body.

Researchers studying white blood cells identified an atlas of genes linked to high production and release of the most common type of antibody found in the human body, known as immunoglobulin G. The finding could be a step toward new antibody-based treatments and improvements in the effectiveness of cell therapies. The researchers used microscopic containers called nanovials, which were developed at UCLA, to capture the individual cells they studied.

The discovery was made possible by UCLA-developed nanotechnology.

In this application note, Luminex describes a novel method involving a uniform hydrogel particle platform, created by Partillion Bioscience, called nanovial. Imaging flow cytometry is then used to simultaneously measure the individual cellular characteristics and secretions released from each specific cell.