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Phase 2 Study of Denifanstat Looks to Add First-in-Class Agent to HER2+Breast Cancer Treatment Armamentarium

Phase 2 trial investigators hope denifanstat can be a key component in restoring sensitivity to HER2- positive metastatic breast cancer treatments.

Minnesota , United-states , Mayo-clinic-in-rochester , Karthikv-giridhar , Division-of-medical-oncology , Department-of-oncology , Breast-tumor-group , Medical-oncology , Mayo-clinic , Phase-efficacy-seen , Advanced-solid-tumors

AURKA Pathway Gains Ground as Targetable Option in Metastatic Breast Cancer

The AURKA inhibitor alisertib has emerged as an agent of particular note, demonstrating early signals of efficacy with a manageable safety profile for the treatment of patients with locally advanced or metastatic breast cancer whose disease is resistant to endocrine therapies.

Mayo-clinic-in-rochester , Minnesota , United-states , American , Karthikv-giridhar , Tufiac-haddad , Antonio-dassoro , Houj-aurora , Digital-health , Mayo-clinic-comprehensive-cancer-center , Mayo-clinic-college-of-medicine , American-society-of-clinical-oncology-annual-meeting