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Microscopy technique reveals hidden nanostructures in cells and tissues

MIT researchers developed a way to “de-crowd” molecules in a cell by expanding a tissue sample, labeling the molecules, then imaging them. The method, known as expansion revealing, builds on a technique known as expansion microscopy and should allow scientists to visualize molecules and cellular structures that have never been seen before. ....

Charles Hieken , Kathleen Octavio , Jinyoung Kang , Edward Boyden , Li Huei Tsai , Asmamaw Wassie , Lisa Yang , John Doerr , Deblina Sarkar , Thomas Blanpied , Margaret Schroeder , Yang Center , University Of Maryland , Mcgovern Institute For Brain Research , National Institutes Of Health , National Science Foundation , Picower Institute For , Autism Research , Koch Institute For Integrative Cancer Research , Ludwig Family Foundation , Us Army Research Office , Howard Hughes Medical Institute , Media Lab , Stan Professor , Govern Institute , Brain Research ,