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Researchers at the Icahn School of Medicine at Mount Sinai have identified an allergy pathway that, when blocked, unleashes antitumor immunity in mouse models of non-small cell lung cancer (NSCLC).
<p style="text-align:justify">Researchers at the Icahn School of Medicine at Mount Sinai have identified an allergy pathway that, when blocked, unleashes antitumor immunity in mouse models of <em>non-small cell lung cancer (</em>NSCLC)<em>. </em> And in an early parallel study in humans, combining immunotherapy with dupilumab<em>—</em>an <a href="https://www.frontiersin.org/articles/10.3389/fimmu.2018.00888/full" target="_blank">Interleukin-4</a> (IL-4) receptor-blocking ant...
In humans, the SLC29A3 gene regulates the function of lysosomes to control waste recycling in cells such as macrophages (that engulf and destroy foreign bodies).
Researchers from Tokyo Medical and Dental University (TMDU) have identified a previously unknown population of cells known as pre-basophils that bridge the gap between pre-basophil and mast cell progenitors (pre-BMPs) and mature basophils along the hematopoietic cell differentiation pathway in mice. These pre-basophils are highly proliferative compared with mature basophils and appear to play a role in the response to helminth infection.