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Clare Marshall, 64, is believed to have walked to Moncreiffe Island in Perth after leaving the city's Dundee Road area in the early hours of Monday. She has not been seen since.
Investigating officers are "concerned" for Ms Marshall's welfare as the search continues on Tuesday.
A specialist police team are scouring the River Tay after a woman went missing in Perth.
Clare Marshall was last seen in the early hours of Monday and may have walked to Moncrieffe Island.
Clare Marshall, from Perth, went missing in the Scottish city in the early hours of Monday morning and police have launched an 'extensive' search for the 64-year-old.